Studies on the Cis-trans geometric isomerization of N-P-coumaroyltyramine
N-p-trans--coumaroyltyramine(N-p-t-CT)can be extracted and isolated from various plants with complex separation process,low yield,and extremely high cost.Previous studies have stated that N-p-t-CT presents various pharmacological activities,including antioxidant,anti-inflammatory,antiviral,and anticancer effects.N-p-t-CT can generate its cis-isomer,N-p-cis-coumaroyltyramine(N-p-c-CT)under illumination,both of which exhibit different biological activities.In order to investigate the biological activities and mechanisms of N-p-t-CT,this study established a simple and rapid HPLC method for the quantitative analysis of N-p-t-CT.Meanwhile,the effects of different light sources,solvents,temperatures,concentrations,and pH on the degree of isomerization of N-p-t-CT were investigated.The results showed that N-p-t-CT was relatively stable under dark,high concentration,low solvent polarity and alkaline conditions,which provides a theoretical basis for further study and applications development.
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