Research Progress in the Synthesis of Anticancer Agents with Quercetin as the Lead Compound
Quercetin is a natural antioxidant,mainly found in vegetables,fruits and other plants.It can regulate many intracellular signaling path-ways related to disease progression,stimulate the immune system,scavenge free radicals,adjust enzyme activity,change the mitotic cycle,inhibit and reverse or delay the occurrence of tumors.However,the low bioavailability of quercetin limits its clinical application.New quercetin derivatives are designed and synthesized through various methods to improve its adverse factors and thereby play a role in preventing and treating diseases.Many quercetin derivatives have been synthesized with excellent properties,good solubility,high bioavailability,stable metabolism,low toxic and side ef-fects,and significant anti-cancer activity.The synthesis of quercetin as the lead compound in recent years is reviewed,focusing on quercetin deriva-tives with anti-cancer activity,and a reference for the further development of quercetin derivatives is provided.
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