Research progress on intestinal flora and pathologic aging
Intestinal flora is colonised in the gastrointestinal tract,where it forms a natural protective barrier.With age,the intestinal flora is affected by external factors such as high salt or high fat diet,long-term medication,bad habits.The composition and abundance of the intestinal flora change,and the harmful flora increase,which causes disorders in the body's endocrine,immune,metabolism and nerves,and induces pathological aging.The change of intestinal flora is one of the important mechanisms that cause pathological aging.Among them,Proteus,Escherichia,Salmonella and other harmful bacteria,lipopolysaccharide,and metabolite trimethlamine activate the inflammatory signaling pathways such as Toll-like receptor 4,NF-κB,C/EBPβ/AEP,and cause the production of inflammatory factors such as NLRP3,IL-6,IL-1β,leading to the occurrence of aging-related diseases,such as Alzheimer's disease,heart failure,hepatitis,renal failure and chronic obstructive lung disease.This review summarizes the mechanisms of intestinal flora in the development of aging and provides new ideas for the study of using intestinal flora as a target for the treatment of aging-related diseases.
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