成人弥漫性低级别胶质瘤相关性癫痫的研究现状
Research status of diffuse low-grade glioma-related epilepsy in adults
廖红展 1刘蒙杰 1段海洋 1夏学巍1
作者信息
- 1. 桂林医学院附属医院,桂林 541001
- 折叠
摘要
癫痫是弥漫性低级别胶质瘤的常见症状,如果不加以控制,则会显著降低患者的生活质量,致残致死率高.肿瘤相关性癫痫的发病是多种因素导致的,且癫痫发作也会促进胶质瘤的生长.相比于高级别胶质瘤,低级别胶质瘤具有更高的癫痫发作率,因此控制癫痫发作对于低级别胶质瘤的治疗极其重要.目前,癫痫的治疗主要围绕抗癫痫药物、放化疗及手术治疗展开.本文综述弥漫性低级别胶质瘤相关性癫痫的发病机制及主要治疗方法,并为未来癫痫的个体化治疗提供研究思路.
Abstract
Epilepsy is a common symptom of diffuse low-grade gliomas.If not controlled,it can significantly reduce the patient's quality of life and result in a high disability and mortality rate.The onset of tumor-associated epilepsy is multifactorial,and seizures also promote the growth of glioma.Compared to high-grade gliomas,low-grade gliomas have a higher incidence of seizures.Therefore,controlling seizures is extremely important for the treatment of low-grade gliomas,and the treatment of epilepsy currently mainly revolves around antiepileptic drugs,radiotherapy,chemotherapy,and surgical treatment.This article summarizes the pathogenesis and main treatment methods of diffuse low-grade glioma-related epilepsy,and provides research ideas for personalized treatment of epilepsy in the future.
关键词
弥漫性低级别胶质瘤/癫痫/瘤周微环境/谷氨酸/γ-氨基丁酸Key words
diffuse low-grade gliomas/epilepsy/peritumoral microenvironment/glutamate/γ-aminobutyric acid引用本文复制引用
基金项目
广西自然科学基金(2017GXNSFBA198001)
出版年
2024
NETL
NSTL
万方数据