Network pharmacology study on Ilex cornuta folium in the treatment of non-alcoholic fatty liver disease
Objective To investigate the biological targets and mechanism action of treatment of non-alcoholic fatty liver disease(NAFLD)effect of Ilex cornuta folium based on network pharmacology.Methods Through the HERB database,SwissADME,and Traditional Chinese Medicine Systems Pharmacology Platform(TCMSP)database,active ingredients of Ilex cornuta folium were screened.Relevant targets were obtained through TCMSP,Swiss Target Prediction,and GeneCards databases.Compound-target-disease and protein-protein interaction(PPI)networks were constructed using Cytospace and STRING.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis were performed using the DAVID database.Results Separate and obtain high concentration compounds of quercetin,kaempferol,and multi stem cabbage chrysanthemum,Vascular endothelial growth factor A(VEGFA),interleukin-1β(IL-1β)and 10 key proteins such as tumor necrosis factor(TNF),enrichment analysis,Ilex cornuta folium treatment of NAFLD may be related to signaling pathways such as TNF,IL-17,advanced glycosylation product(AGE)-receptor for advanced glycosylation end products(RAGE),and molecular docking analysis showed good docking of key compounds and key targets.Conclusion Ilex cornuta folium treat NAFLD by modulating TNF,IL-17,AGE-RAGE,CLR and TLR signaling pathways.
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