Effects of Bedaquiline Fumarate combined with 2HVZE/4HVE regimen on rifampicin resistant pulmonary tuberculosis patients
Objective To analyse the effect of Bedaquiline Fumarate combined with 2HVZE/4HVE regimen on sputum negative conversion rate and serum cytokine levels in patients with rifampicin resistant pulmonary tuberculosis.Methods 86 patients with rifampicin resistant pulmonary tuberculosis in our hospital were divided into Group A and Group B by random number table method,with 43 cases in each group.Group B was treated with 2HVZE/4HVE regimen,and Group A was treated with Bedaquiline Fumarate combined with 2HVZE/4HVE regimen.The clinical efficacy,cavity closure rate,focus absorption rate,sputum negative conversion rate,immune function indexes,serum procalcitonin(PCT),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),glutathione S-transferase-π(GSTπ)levels and incidence of adverse reactions were compared between the two groups.Results After 6 months of treatment,the clinical total effective rate,cavity closure rate,focus absorption rate,sputum negative conversion rate and immune function index levels in Group A were higher than those in Group B.And the serum GSTπ,IL-6,TNF-α,PCT levels in Group A were lower than that in Group B,with a statistically significant difference(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The adjunctive treatment of Bedaquiline Fumarate is effective in the treatment of rifampicin resistant pulmonary tuberculosis patients patients,which can alleviate the clinical symptoms,regulate immune function and promote the improvement of disease.
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