首页|辅助生殖技术中卵巢过度刺激综合征危险因素及针刺干预效果分析

辅助生殖技术中卵巢过度刺激综合征危险因素及针刺干预效果分析

Risk factors and acupuncture intervention effect analysis of ovarian hyperstimulation syndrome in assisted reproductive technology

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目的 分析辅助生殖技术(ART)中发生卵巢过度刺激综合征(OHSS)的危险因素,观察针刺干预效果.方法 选取123 例实施ART治疗的不孕患者,将未发生OHSS的 70 例为对照组,将发生OHSS的 53 例为合并组,分析ART中发生OHSS的危险因素,观察针刺干预的效果.结果 年龄、BMI、FSH、LH、AMH、扳机日E2、AFC、Gn首次用药量、Gn总用量、Gn天数是影响不孕患者ART治疗中发生OHSS的独立因素.年龄<28 岁、BMI<20 kg/m2、LH≥5 mIU/mL、AMH≥4 ng/mL、AFC≥20 个、Gn首次用药量>200 IU、Gn总用量>3 000 IU、Gn时间>10 d、扳机日E2 水平>4 000 pg/mL为导致不孕患者ART中发生OHSS的危险因素.针刺干预后,OHSS患者LH、AMH、全胚冻存率均低于干预前,获卵数量高于干预前(P<0.05).结论 年龄小、BMI指数低,LH、AMH水平高,AFC数量多,Gn用药量大、应用时间长以及扳机日E2水平高均为ART期间诱发OHSS的危险因素.针刺干预可降低OHSS患者的性激素水平及全胚冻存率并提升获卵数.
Objective To analyze the risk factors for ovarian hyperstimulation syndrome(OHSS)in assisted reproductive technology(ART)and observe the effectiveness of acupuncture intervention.Methods 123 infertile patients who underwent ART treatment were selected,70 cases without OHSS were included in the control group,and 53 cases with OHSS were included in the combined group.The risk factors of ART were analyzed,and the effect of acupuncture intervention was observed.Results Age,BMI,FSH,LH,AMH,trigger day E2,AFC,initial dose of Gn,total dose of Gn,and Gn days were independent factors affecting the occurrence of OHSS in ART treatment for infertile patients.Age<28 years old,BMI<20 kg/m2,LH baseline value≥5 mIU/mL,AMH≥4 ng/mL,AFC≥20,Gn initial dosage>200 IU,Gn total dosage>3 000 IU,Gn time>10 d,trigger day E2level>4 000 pg/mL are risk factors for OHSS during ART in infertile patients.After acupuncture intervention,the LH,AMH and whole embryo freezing rate of OHSS patients were lower than that before intervention,and the number of eggs obtained was higher than that before intervention(P<0.05).Conclusion Young age,low BMI index,high LH and AMH levels,high AFC,high Gn dosage,long duration,and high E2 levels on trigger day are risk factors for OHSS during ART.Acupuncture intervention can reduce sexual hormone levels and OHSS whole embryo cryopreservation rate in patients with OHSS,and increase the number of retrieved eggs.

assisted reproductive technologyovarian hyperstimulation syndromesexual hormonesgonadotropinrisk factorsacupuncture intervention

王子涵

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商丘市第一人民医院妇科二病区,商丘 476100

辅助生殖技术 卵巢刺激综合征 性激素 促性腺激素 危险因素 针刺干预

河南省医学科技攻关计划

LHGJ2021012412

2024

华夏医学
桂林医学院

华夏医学

影响因子:0.569
ISSN:1008-2409
年,卷(期):2024.37(1)
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