Applied value of Heocoagulase Bothrops Atrox from agkistrodon halys venom in postoperative hemostasis of bladder cancer after TURBT
Objective To observe the application effect Heocoagulase Bothrops Atrox on hemostasis after transurethral resection of bladder tumors(TURBT).Methods 98 cases of bladder cancer treated by TURP were divided into two groups using random mumber table method.49 cases in the conventional group were treated with routine electrocoagulation for hemostasis after operation,and 49 cases in the test group were treated with local application of Heocoagulase Bothrops Atrox from agkistrodon halys spear after operation.The hemostasis effect,coagulation function and prognosis of the two groups were compared.Results After treatment,the amount of postoperative bleeding,bladder flushing time,urine clearance time and catheter retention time in the test group were lower than those in the conventional group,with statistically significant differences(P<0.05),and the APTT,PT,TT,PAI-1,t-PA in the test group were slightly higher than those in the conventional group,with no statistically significant difference(P>0.05).The postoperative BC and Qmax in the experimental group were higher than those in the conventional group,while the BSSS score and postoperative complication rate were lower than those in the conventional group(P<0.05).Conclusion Local administration of Heocoagulase Bothrops Atrox after TURBT can produce significant hemostatic effects without affecting the coagulation function and fibrinolytic system function of patients,and has a positive significance in promoting postoperative bladder function recovery and reducing the risk of complications.
bladder cancertransurethral resection of bladder tumorsHeocoagulase Bothrops Atroxhemostatic effectcoagulation function
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