Buyang Huanwu decoction for treatment of hemodialysis syndrome and abnormal iron metabolism in AKI patients
Objective To observe the therapeutic effects of modified Buyang Huanwu decoction on hemodialysis syndrome and iron metabolism in patients with acute kidney injury(AKI).Methods 112 AKI patients were divided into two groups the conventional group and traditional Chinese medicine group using a random number table method,with 56 cases in each group.The conventional group were treated with sucrose iron assisted maintenance hemodialysis(MHD).The traditional Chinese medicine group were treated with modified Buyang Huanwu decoction as an adjunct to MHD.The changes in iron metabolism,blood lipids,hemodynamics,and the occurrence of restless leg syndrome(RLS)were compared between two groups of patients after treatment.Results After treatment,the serum iron(SI),serum ferritin(SF),and serum transferrin saturation(TFS)of the traditional Chinese medicine group were higher than those of the conventional group.Total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),plasma viscosity,whole blood high shear viscosity,and whole blood low shear viscosity were all lower than those of conventional methods.The incidence of non-twisted leg syndrome in the traditional Chinese medicine group was lower than that in the conventional group at the first,third,and sixth month of follow-up(P<0.05).Conclusion Modified Buyang Huanwu decoction can effectively alleviate hemodialysis induced iron metabolism abnormalities in AKI patients with MHD,promote hemodynamic recovery,and reduce the risk of RLS.
acute kidney injurymaintenance hemodialysisrestless leg syndromeBuyang Huanwu decoctioniron metabolism
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