Effect of comparison on postoperative temozolomide chemotherapy and radioknife radiotherapy for gliomas
Objective To observe the short-term and long-term effects of Temozolomide(TMZ)chemotherapy and radioknife radiotherapy in patients with glioma after surgery.Methods 87 patients with glioblastoma were selected and divided into the chemotherapy group(43 cases)and radiotherapy group(44 cases)by drawing lots.The chemotherapy group were received TMZ chemotherapy,while the radiotherapy group were received radioknife radiotherapy.The changes in various biomarker levels and lesion improvement after treatment were compared between the two groups,as well as the quality of life and incidence of adverse events during the follow-up period.Results After treatment,there was no statistically significant difference in the levels of carbohydrate antigen 153(CA153),neuron specific enolase(NSE),asparagine endopeptidase(AEP),tumor proliferation marker(Ki-67),objective response rate(ORR),and disease control rate(DCR)between the two groups of patients(P>0.05).During the follow-up period,the Karnofsky performance status(KPS)and quality of life score(QOL)of tumor patients in the radiotherapy group were higher than those in the chemotherapy group,while the zubrod performance status(ZPS)was lower than that in the chemotherapy group.The incidence of adverse events was lower than that in the chemotherapy group,and the differences were statistically significant(P<0.05).Conclusion The application of TMZ chemotherapy or radioknife radiotherapy has positive significance in controlling the postoperative progression of glioma patients,but radioknife radiotherapy has clinical advantages in improving patient quality of life and reducing the risk of adverse events.
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