Research progress in the therapeutic application of tissue-resident memory T cells in solid tumors
There are a large number of immune cells in the blood circulation,which are capable of preventing infection and invasion by pathogenic microorganisms and also play an important role in tumor progression.Tissue-resident momory T cells(TRM)are a special subset of tumor infiltrating lymphocytes that can indefinitely reside in tissues and respond rapidly to their homologous antigens.TRM consists of two subgroups,CD4+and CD8+,both characterized by the expression of CD69 and CD103 markers,which activate innate and adaptive immune responses through the production of cytotoxic cytokines.The role of TRM in slowing down tumor occurrence and development,inhibiting metastasis,and reducing tumor recurrence has been confirmed in various solid tumors.In order to further investigate the biological characteristics and immune mechanism of these cells,based on literature review,the basic biological characteristics of tissue resident memory T cells were combed,and the role and research progress of CD8+TRM cells in the treatment of solid tumors such as breast cancer,non-small cell lung cancer and liver cancer were reviewed,aiming to provide new strategies and targets for tumor treatment.
tissue-resident memory T cellsCD103CD69solid tumors
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