首页|PBK/TOPK在类风湿关节炎患者单核细胞中的表达及临床意义

PBK/TOPK在类风湿关节炎患者单核细胞中的表达及临床意义

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目的 研究PDZ结合激酶/T-淋巴因子激活的杀伤细胞来源的蛋白激酶(PBK/TOPK)在类风湿关节炎(RA)患者单核细胞的表达及临床意义。方法 以47 例RA患者、20 例健康体检者为研究对象，采用流式细胞术检测外周血单个核细胞(PBMC)中PBK/TOPK的表达。结果 PBK/TOPK在RA患者CD14+单核细胞表达水平高于健康体检者，差异具有统计学意义(P<0。05)。RA患者CD14+单核细胞PBK/TOPK低表达组CD14+单核细胞在 PBMC 中所占比例、白细胞(WBC)计数、类风湿因子(RF)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)的水平均高于PBK/TOPK高表达组，差异具有统计学意义(P<0。05)。RA住院患者单核细胞PBK/TOPK表达低于门诊患者，且住院患者RF水平高于门诊患者，差异具有统计学意义(P<0。05)。结论 单核细胞 PBK/TOPK低表达与疾病炎症有关，对类风湿关节炎的靶向治疗有一定意义。
Expression and clinical significance of PBK/TOPK in monocytes of patients with rheumatoid arthritis
Objective To investigate the expression and clinical significance of PDZ-binding-kinase/T-LAK cell-derived protein kinase(PBK/TOPK)in monocytes of patients with rheumatoid arthritis(RA).Methods PBK/TOPK expression in peripheral blood mononuclear cells(PBMC)was detected by flow cytometry in 47 RA patients and 20 healthy subjects.Results The expression level of PBK/TOPK in peripheral blood CD14+monocytes in RA patients was higher than that in healthy subjects,and the difference was statistically significant(P<0.05).The proportion of CD14+monocytes in PBMC,white blood cell(WBC)count,rheumatoid factor(RF),immunoglobulin A(IgA)and immunoglobulin G(IgG)of CD14+monocytes in RA patients with low expression of PBK/TOPK were higher than those in RA patients with high expression of PBK/TOPK.The difference was statistically significant(P<0.05).The monocyte PBK/TOPK expression in inpatients with RA was lower than that in outpatients,and the RF level in inpatients was higher than that in outpatients.The difference was statistically significant(P<0.05).Conclusion The low expression of PBK/TOPK in monocytes is related to the inflammation of the disease,and it has certain significance for the targeted therapy of RA.

PD2-binding-kinase/T-LAK cell-originated protein kinaserheumatoid arthritismonocyte

王琪、覃泱、臧念可、刘瑜、辛林伟、魏兵

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桂林医学院公共卫生学院,桂林 541199

广西肿瘤免疫与微环境调控重点实验室,桂林 541199

桂林医学院附属医院,桂林 541001

桂林医学院第二附属医院,桂林 541199

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PBK/TOPK 类风湿关节炎 单核细胞

国家自然科学基金地区科学基金广西自然科学基金面上项目广西脑与认知神经科学重点实验室开放课题(2020)广西肿瘤免疫与微环境调控重点实验室开放基金广西医疗卫生重点培育学科建设项目

823603302020JJA140128GKLBCN-20200108-062202KF004

2024

10.19296/j.cnki.1008-2409.2024-02-014

华夏医学
桂林医学院

华夏医学

影响因子：0.569
ISSN：1008-2409
年,卷(期)：2024.37(2)
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