Expression and significance of C12ORF49 in breast cancer based on Bioinformatic data
Objective To analyze the expression,clinical significance and interacting protein function of chromosome 12 open reading frame 49(C12ORF49)in breast cancer through online databases,and to provide a new approach for the prevention,treatment and prognosis of breast cancer.Methods The Oncomine database and the Human Protein Atlas(HPA)database were used to analyze the differential expression of C12ORF49 gene and protein in breast cancer,and the Kaplan-Meier Plotter database was applied to analyze the correlation between C12ORF49 expression levels and the prognosis of breast cancer patients with different pathological features,and finally the STRING database was employed to map the C12ORF49-related reciprocal protein network and KEGG functional enrichment analysis was performed in KOBAS bioanalysis platform to predict its biological function.Results C12ORF49 expression was higher in breast cancer tissues than that in normal tissues.Overall survival time(OS)and distant metastasis-free survival time(DMFS)were shorter in the breast cancer patients with high C12ORF49 mRNA expression than that in the breast cancer patients with low C12ORF49 mRNA expression,and the difference was statistically significant(P<0.05);C12ORF49 predicted poor DMFS prognosis in patients with Luminal B breast cancer(P<0.05).The effect of C12ORF49 on poor DMFS prognosis of breast cancer was probably independent of the expression profile of breast cancer receptor.These physiological processes such as NF-κB signaling pathway,TCR signaling pathway and platelet activation were associated with C12ORF49-boosted breast cancer(P<0.01,Corrected-P<0.01),promoted the progress of breast cancer.Conclusion C12ORF49 is upregulated in breast cancer tissues,and is important for the prognosis of breast cancer patients,which is worth the further study.
chromosome 12 open reading frame 49breast cancerBioinformatics
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