Preventive and therapeutic effects of different administration times of indomethacin on postoperative complications of esophageal cancer ERCP
Objective To observe the effect of different administration times of indomethacin on postoperative complications of endoscopic retrograde cholangiopancreatography(ERCP)for esophageal cancer.Methods 107 esophageal cancer patients who underwent ERCP were randomly divided into two groups using a number table method.The control group consisted of 53 patients who were received rectal injection of indomethacin for treatment within 2 h after surgery.The observation group consisted of 54 patients who were received preoperative rectal injection of indomethacin for treatment.The postoperative complications,serum amylase(AMS)levels,inflammatory reactions,and prognosis of the two groups of patients were compared.Results The incidence of postoperative complications and AMS levels at 6 h,12 h,and 24 h after surgery in the observation group were lower than those in the control group,and difference was statistically significant(P<0.05);1 d after surgery,IL-6,CRP,TNF-α in the observation group were lower than the control group(P<0.05);the median progression-free surrival(PFS)and median overall surrival(OS)of the observation group were higher than those of the control group,and the mortality rate was lower than that of the control group(P<0.05).Conclusion Preoperative rectal injection of indomethacin combined with ERCP treatment can reduce the risk of postoperative complications in esophageal cancer,inhibit the levels of various inflammatory indicators,and improve patient prognosis,which has a positive significance.
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