Diagnostic performance of Gd-EOB-DTPA enhanced MRI in portal venous phase non-washout hepatocellular carcinoma
Objective To investigate the diagnostic performance of Gd-EOB-DTPA enhanced MRI for small hepatocellular carcinoma(sHCC)non-washout in portal venous phase with high risk for hepatocellular carcinoma(HCC).Methods 44 patients with high-risk for HCC underwent Gd-EOB-DTPA-enhanced MRI,in total 50 nodules non-washout in portal venous phase and further pathological diagnosis was underwent by surgical resection or puncture biopsy.The difference between groups of liver nodule image features and the diagnostic performance of the model based on the image features was analyzed.Results Among the nodule non-washout in the portal venous phase of Gd-EOB-DTPA enhanced MRI,there were statistically significant differences between sHCC and Non-sHCC groups in nonrim-like enhancement in arterial phase,transitional phase hypointensity,nodular capsule,restricted diffusion in DWI,mild-moderate T2 hyperintensity,and hypointensity in T1WI(P<0.05).Multivariate logistic regression analysis showed that the transitional phase hypointensity,nodular capsule were independent risk factors for sHCC.The sensitivity,specificity and accuracy of transitional phase hypointensity,nodular capsule and the combined diagnosis of sHCC non-washout in portal venous phase were 72.7%,70.6%,72.0%,78.8%,94.1%,84.0%and 93.9%,70.6%,86.0%,respectively.The areas under ROC curve were 0.717,0.865 and 0.905,respectively.Conclusion With high risk for HCC,Gd-EOB-DTPA enhanced MRI has high diagnostic efficiency in portal venous phase non-washout hepatocellular.The combination of low signal during migration and analysis of nodular capsule sign can further improve the diagnostic efficacy of Gd-EOB-DTPA which enhanced the diagnostic efficiency of MRI in portal venous phase non-washout hepatocellular.
small hepatocellular carcinomaGd-EOB-DTPAwashout in portal venous phasetransitional phase hypointensity
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