Effects of intraoperative insulation on postoperative coagulation and fibrinolytic system in patients undergoing congenital heart disease surgery
Objective To observe the effect of intraoperative insulation measures on postoperative coagulation and fibrinolysis systems in patients with congenital heart disease(referred to as"congenital heart disease").Methods 126 children with congenital heart disease were selected as the research subjects and randomly divided into two groups,with 63 cases in each group.Both groups were received interventional closure surgery,while the control group were received routine treatment,while in the intervention group,active insulation measures were taken to assist in treatment.The coagulation function,fibrinolytic system,dynamic balance parameters of coagulation fibrinolytic system,and surgical stress were compared between the two groups of children.Results Under different treatment regimens,the activated partial thrombin time(APTT),thrombin time(TT),and prothrombin time(PT)of the intervention group were lower than those of the control group,with a statistically significant difference(P<0.05).The platelet count(PLT)and fibrinogen(FIB)of the intervention group were higher than those of the control group,while the D-dimer(D-D)was lower than that of the control group(P<0.05).The coagulation start time(CST),complete fibrinolysis time(WFT),and equilibrium time(BLT)of the intervention group were all lower than those of the control group.The levels of norepinephrine(NE),cortisol(Cor),and angiotensin Ⅱ(Ang Ⅱ)in the intervention group were lower than those in the control group(P<0.05).Conclusion Intraoperative insulation can effectively improve the coagulation function and fibrinolytic system function of children with congenital heart disease,maintain the dynamic balance of the coagulation fibrinolytic system.
NETL
NSTL
万方数据
