Effects of amoxicillin and clavulanate potassium in the prevention and treatment of postoperative infection in prostate hyperplasia patients undergoing TURP surgery
Objective To observe the preventive and therapeutic effects of amoxicillin and clavulanate potassium on postoperative infections in patients with benign prostatic hyperplasia undergoing transurethral resection of prostate(TURP).Methods 112 patients with benign prostatic hyperplasia were selected and randomly divided into two groups.The patients were received TURP surgery,while the control group had 56 patients who were received routine anti infection treatment after surgery.The observation group had 56 patients who were received adjuvant treatment with amoxicillin and clavulanate potassium after surgery.The improvement of inflammatory and immune indicators,incidence of postoperative infection,and medication safety between the two groups patients were compared.Results After treatment,the CRP and IL-10 levels in the observation group were lower than those in the control group,and the expression levels of CD4+/CD3+and CD4+/CD8+on T lymphocytes were higher than those in the control group.The expression levels of CD8+/CD3+and the incidence of postoperative infection were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of drug-related side effects between the two groups(P>0.05).Conclusion Amoxicillin clavulanate potassium assisted TURP can effectively improve inflammatory indicators and enhance immune function in patients with benign prostatic hyperplasia,and has a positive effect on reducing the risk of postoperative infection.Moreover,the combined use of this drug do not significantly increase the risk of adverse reactions,and the medication safety is relatively high.
amoxicillin and clavulanate potassiumprostate hyperplasiaprostatectomypostoperative infectiondrug safety
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