高频重复经颅磁刺激配合抗凝在脑梗死治疗中的应用
Application of high-frequency repetitive transcranial magnetic stimulation combined with anticoagulant therapy in the treatment of cerebral infarction
陈晨 1田萌1
作者信息
- 1. 南阳医学高等专科学校第一附属医院神经内科,南阳 473000
- 折叠
摘要
目的 观察高频重复经颅磁刺激(rTMS)配合抗凝治疗对改善脑梗死患者神经、认知功能的应用效果.方法 选取132 例脑梗死患者,随机分为观察组和对照组,每组66 例.对照组接受药物抗凝治疗,观察组在此基础上联合应用rTMS 治疗,比较两组治疗前后的脑神经功能、认知功能改善情况及不良事件发生情况.结果 治疗后,观察组NIHSS、NSE、S100-β的评分均低于对照组,差异具有统计学意义(P<0.05);UA高于对照组,Hcy、NF-L均低于对照组(P<0.05).观察组MMSE、MoCA的评分均高于对照组(P<0.05),不良事件发生率低于对照组(P<0.05).结论 在予以脑梗死常规药物抗凝治疗同时联合应用rTMS可促进患者脑神经功能及认知功能改善,还可降低脑血管不良事件发生风险.
Abstract
Objective To observe the application effect of high-frequency repetitive transcranial magnetic stimulation(rTMS)combined with anticoagulant therapy on improving neurological and cognitive function in patients with cerebral infarction.Methods 132 patients with cerebral infarction were selected and randomly divided into the observation group and control group,with 66 cases in each group.The control group were received anticoagulant therapy,while the observation group were received rTMS treatment in combination.The brain nerve function,cognitive function,and incidence of adverse events before and after treatment were compared between the two groups of patients.Results After treatment,the scores of NIHSS,NSE,and S100-β in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05);in the observation group,UA was higher than that in the control group,while Hcy and NF-L were lower than that in the control group(P<0.05).The MMSE and MoCA scores of the observation group were higher than those of the control group(P<0.05).The incidence of adverse events in the observation group was lower than that in the control group(P<0.05).Conclusion The combination of conventional anticoagulant therapy with rTMS for cerebral infarction can promote the improvement of patients'neurological and cognitive functions,and reduce the risk of cerebrovascular adverse events.
关键词
脑梗死/抗凝治疗/高频重复经颅磁刺激/神经功能/认知功能Key words
cerebral infarction/anticoagulant therapy/high-frequency repetitive transcranial magnetic stimulation/nerve function/cognitive function引用本文复制引用
基金项目
河南省医学科技攻关计划(LHGJ2021003321)
出版年
2024
NETL
NSTL
万方数据