Application of high-frequency repetitive transcranial magnetic stimulation combined with anticoagulant therapy in the treatment of cerebral infarction
Objective To observe the application effect of high-frequency repetitive transcranial magnetic stimulation(rTMS)combined with anticoagulant therapy on improving neurological and cognitive function in patients with cerebral infarction.Methods 132 patients with cerebral infarction were selected and randomly divided into the observation group and control group,with 66 cases in each group.The control group were received anticoagulant therapy,while the observation group were received rTMS treatment in combination.The brain nerve function,cognitive function,and incidence of adverse events before and after treatment were compared between the two groups of patients.Results After treatment,the scores of NIHSS,NSE,and S100-β in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05);in the observation group,UA was higher than that in the control group,while Hcy and NF-L were lower than that in the control group(P<0.05).The MMSE and MoCA scores of the observation group were higher than those of the control group(P<0.05).The incidence of adverse events in the observation group was lower than that in the control group(P<0.05).Conclusion The combination of conventional anticoagulant therapy with rTMS for cerebral infarction can promote the improvement of patients'neurological and cognitive functions,and reduce the risk of cerebrovascular adverse events.
cerebral infarctionanticoagulant therapyhigh-frequency repetitive transcranial magnetic stimulationnerve functioncognitive function
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