Chlorphenamine maleate combined with mometasone furoate in the treatment of allergic dermatitis
Objective To analyze the efficacy of mometasone furoate combined with chlorphenamine maleate in the treatment of allergic dermatitis.Methods 94 patients with allergic dermatitis were conducted.According to different treatment methods,they were divided into the control group and observation group,with 47 cases in each group.The control group were treated with chlorphenamine maleate,and the observation group were treated with mometasone furoate on the basis of the control group.The Dermatology Life Quality Index(DLQI)and the lesion area score were used to evaluate the quality of life and the state of the lesions in both groups.The levels of serum interferon-gamma(IFN-γ)and interleukin-4(IL-4)were measured by enzyme-linked immunosorbent assay.Results The total clinical efficacy rate in the observation group was 91.49%higher than 74.47%in the control group,with a statistically significant difference(P<0.05).After treatment,the remission time of symptoms such as redness,itching,wheal,and peeling in the observation group was shorter than that in the control group(P<0.05).The DLQI score,lesion area score,and the level of IL-4 in the observation group were lower than those in the control group,while the level of IFN-γ was higher than that in the control group(P<0.05).The total incidence of adverse reactions in the two groups showed no significant difference(P>0.05).Conclusion Mometasone furoate combined with chlorphenamine maleate has significant therapeutic effects in the treatment of allergic dermatitis,with alleviating clinical symptoms and better improving the quality of life of patients.
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