Application of sequential therapy of cephalosporin in children with pneumonia
Objective To observe the efficacy and safety of sequential therapy of cephalosporin in children with pneumonia.Methods 110 children with pneumonia were selected and divided into two groups using a random number table method,with 55 cases in each group.The conventional group were treated with routine drugs,and the sequential group were treated with cephalosporin.The symptom relief time,inflammatory factors,immune indicators,drug safety and medical costs of the two groups were compared.Results After treatment,the relief time of symptoms such as cough,inspiratory triple concave sign,and fever in the sequential group was lower than that in the conventional group,and the bacterial clearance rate in the sequential group was higher than that in the conventional group,with a statistically significant differences(P<0.05);the levels of CD3+and CD4+in the sequential group were higher than those in the conventional group,while the level of CD8+was lower than that in the conventional group(P<0.05);the incidence of C-reactive protein(CRP),procalcitonin(PCT),interleukin 6(IL-6)and drug-related adverse reactions in the sequential group were lower than those in the conventional group;the hospitalization time,total treatment duration,and total medical expenses of the sequential group were all lower than those of the conventional group(P<0.05).Conclusion The sequential therapy of cephalosporin can speed up the rehabilitation process of children with pneumonia,and has positive significance in enhancing the body immunity,alleviating inflammatory reaction,improving drug safety and reducing medical costs.
children with pneumoniacephalosporinsequential therapyrehabilitation processdrug safety
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