Correlation and diagnostic value of serum PCT and MCP-1 levels with the severity of neonatal bacterial sepsis
Objective To analyze the correlation and diagnostic value between serum procalcitonin(PCT),monocyte chemotactic protein-1(MCP-1),and the severity of neonatal bacterial sepsis.Methods 100 neonates with bacterial sepsis were selected as the study group,and 100 neonates with common bacterial infections during the same period served as the control group.The serum PCT levels,MCP-1 levels,SOFA scores,and PCIS scores of two groups at enrollment were compared,and analyzed the correlation between serum PCT and MCP-1 levels and the severity of neonatal bacterial sepsis(SOFA score,PCIS score)were compared.The value of combined detection of serum PCT and MCP-1 levels in the diagnosis of neonatal bacterial sepsis were analyzed.Results When enrolled,the serum levels of PCT,MCP-1,and SOFA in the study group were higher than those in the control group,while the PCIS score was lower than that in the control group,with a statistically significant difference(P<0.05).The levels of serum PCT and MCP-1 were positively correlated with SOFA score,but negatively correlated with PCIS score(P<0.05).The area under the ROC curve(AUC)of the combined diagnosis of serum PCT and MCP-1 levels for neonatal bacterial sepsis was greater than that of single indicator diagnosis(P<0.05).Conclusion The serum levels of PCT and MCP-1 are closely related to the severity of neonatal bacterial sepsis,and their combined detection has high diagnostic value for neonatal bacterial sepsis.
NETL
NSTL
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