摘要
目的 观察茵陈五苓糖浆结合益生菌对新生儿黄疸临床症状改善及康复进程的影响.方法 以 125 例新生儿黄疸患儿为研究对象,按照随机数字表法分为两组.对照组 62 例,予以常规治疗及益生菌治疗;观察组63 例,在对照组治疗基础上联用茵陈五苓糖浆.比较两组的症状康复进程、血清胆红素水平改善情况、肝脏代谢功能、炎症反应变化情况及用药安全性.结果 治疗后,观察组的皮肤黄染消退时间、退热时间、胃肠不适恢复时间、住院时间均短于对照组,差异具有统计学意义(P<0.05).治疗 3d、7d后,TBIL、间接胆红素、ALT、γ-GT、ALP、CRP、IL-6、TNF-α的水平均低于对照组(P<0.05).观察组的药物相关不良反应发生率与对照组比较,差异无统计学意义(P>0.05).结论 茵陈五苓糖浆结合益生菌能加快新生儿黄疸的康复进程,有效降低胆红素水平,促进肝脏代谢功能恢复,安全性较高.
Abstract
Objective To observe the effects of Yinchen Wuling Syrup combined with probiotics on the improvement of clinical symptoms and rehabilitation process in neonatal jaundice.Methods 125 cases with neonatal jaundice were selected and randomly divided into two groups using a random number table method.62 cases in the control group were treated with conventional therapy and probiotic therapy,while 63 cases in the observation group were treated with Yinchen Wuling Syrup in combination with the conventional and probiotic therapy.The symptom recovery progress,improvement of serum bilirubin levels,changes in liver metabolic function,inflammatory response,and medication safety between the two groups were compared.Results After treatment,the observation group had lower time for skin yellow staining to subside,fever to subside,gastrointestinal discomfort to recover,and hospital stay than those in the control group,with statistically significant difference(P<0.05).After 3 and 7 d treatment,the levels of TBIL,indirect bilirubin,ALT γ-GT,ALP,CRP,IL-6,TNF-α in the observation group were all lower than those in the control group(P<0.05).The incidence of drug-related adverse reactions in the observation group was slightly higher than that in the control group,and the difference was not statistically significant(P>0.05).Conclusion Yinchen Wuling Syrup combined with probiotics accelerate the recovery process of neonatal jaundice,reduce bilirubin levels,promote liver metabolic function recovery effectively,and have a higher drug safety.
基金项目
河南省医学科技攻关计划(LHGJ202001165)
NETL
NSTL
万方数据