Research progress of HIF-1α in tumor biological function
Hypoxia inducible factor-1α(HIF-1α)is a key transcription factor in cancer progression and an important target for cancer-targeted therapy and its activity depends on the presence or absence of oxygen.In an aerobic environment,HIF-1α is completely inactivated and degraded through the ubiquitin-proteasome pathway.On the contrary,in hypoxic environments,HIF-1α accumulates in the nucleus and subsequently upregulates several genes related to cancer progression.HIF-1α is highly expressed in various types of tumor tissues,and its overexpression,along with downstream genes,supports cancer progression through various mechanisms such as vascular mimicry,glycolysis,invasion,migration,immune escape,and tumor drug resistance.Targeting HIF-1α and its downstream signaling molecules can regulate the development and progression of cancer.Therefore,regulating HIF-1 α,mRNA,and protein levels become new pathways for inhibiting cancer.Considering targeted therapy against HIF-1α and related pathway regulatory factors may become a new therapeutic approach for various malignant tumors,so this article reviews the role of HIF-1α in tumor cell biology and the mechanisms of related drugs.
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