血浆EBV-DNA联合窄带成像技术在鼻咽癌复发监测中的应用价值
Application value of plasma EBV-DNA combined with narrow-band imaging technology in the monitoring of nasopharyngeal carcinoma recurrence
覃丽玲 1孔令平 1林贤俊 1赵海云 1林高娟 2莫规兴1
作者信息
- 1. 广西壮族自治区南溪山医院 耳鼻咽喉头颈外科,桂林 541002
- 2. 广西壮族自治区南溪山医院 头颈肿瘤科,桂林 541002
- 折叠
摘要
目的 探讨血浆EB病毒DNA(EBV-DNA)联合窄带成像技术(NBI)在鼻咽癌(NPC)复发监测中的应用价值.方法 选取 NPC 复发患者 86 例和未复发患者 142 例为研究对象,观察 EBV-DNA、NBI、EBV-DNA联合NBI方法在NPC复发诊断中的灵敏度、特异度、阳性预测值、阴性预测值、一致性检验(Kappa值);采用受试者工作特征曲线(ROC)分析EBV-DNA、NBI、EBV-DNA联合NBI诊断NPC复发的曲线下面积(AUC).结果 ROC 分析结果显示,EBV-DNA、NBI、EBV-DNA 联合NBI诊断NPC复发的AUC分别为0.826、0.845、0.893,EBV-DNA联合NBI预测复发的AUC比单一方法检测大,差异具有统计学意义(P<0.05).分层分析结果显示,预测早期患者NPC复发和晚期NPC复发的AUC为 0.924 和 0.865,Kappa 值为 0.827 和 0.696.结论 在监测 NPC 复发诊断中,EBV-DNA联合NBI方法比单一方法效能高,在临床分期为早期的NPC患者中效果更佳,值得临床上应用推广.
Abstract
Objective To explore the application value of plasma epstein barr-virus DNA(EBV-DNA)combined with narrow-band imaging(NBI)in monitoring the recurrence of nasopharyngeal carcinoma(NPC).Methods 86 patients with recurrent NPC and 142 patients without recurrence were enrolled.The sensitivity,specificity,positive predictive value,negative predictive value,and consistency test(Kappa value)of EBV-DNA,NBI,and EBV-DNA combined with NBI method in the diagnosis of NPC recurrence were observed.Receiver operating characteristic curve(ROC)was used to analyze the area under the curve(AUC)of EBV-DNA,NBI,and EBV-DNA combined with NBI for diagnosing NPC recurrence.Results ROC curve analysis results showed that the AUC of plasma EBV-DNA,NBI and combined diagnosis of NPC recurrence were 0.826,0.845 and 0.893,respectively,and the AUC of plasma EBV-DNA combined with NBI was greater in predicting recurrence,with a statistically significance difference(P<0.05).The stratified analysis showed that the AUC for predicting the recurrence of NPC in early and late patients was 0.924 and 0.865,and the Kappa value was 0.827 and 0.696.Conclusion In monitoring the diagnosis of NPC recurrence,the EBV-DNA combined with NBI method is more effective than a single method and is more effective in early-stage NPC patients.It is worthy of clinical application and promotion.
关键词
鼻咽癌/复发监测/窄带成像技术/EB病毒DNAKey words
nasopharyngeal carcinoma/recurrence monitoring/narrow-band imaging technology/epstein barr-virus DNA引用本文复制引用
基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190301)
出版年
2024
NETL
NSTL
万方数据