冻融胚胎周期中应用低分子肝素对PCOS患者妊娠结局的影响
Effects of the application of low-molecular-weight heparin in frozen-thawed embryo cycles on pregnancy outcome in patients with PCOS
温肖依 1邱颖婷 1刘禧 1苏迎春 1肖茸 1漆艳萍1
作者信息
摘要
目的 探讨在冻融胚胎周期中应用低分子肝素(LMWH)改善子宫动脉血流阻力对多囊卵巢综合征(PCOS)患者妊娠结局的影响.方法 83 例PCOS患者依据冻融胚胎移植(FET)期间是否使用LMWH分为对照组(40 例)与观察组(43 例).分析两组子宫内膜血流相关指标[搏动指数(PI)、阻力指数(RI)、收缩末期与舒张末期血流速度比值(S/D)]、妊娠结局及不良反应.结果 治疗后,观察组子宫内膜血流PI、RI及S/D低于对照组,胚胎种植率 66.23%高于对照组 48.61%,差异有统计学意义(P<0.05);早期流产率5.71%低于对照组的 28.57%(P<0.05);两组临床妊娠率及不良反应发生率比较,差异无统计学意义(P>0.05).结论 在冻融胚胎周期中应用LMWH治疗,可改善PCOS患者子宫动脉血流情况,提高胚胎种植率,改善患者妊娠结局.
Abstract
Objective To investigate the effects of low-molecular-weight heparin(LMWH)applied to improve uterine arterial resistance to blood flow in frozen-thawed embryo cycles on pregnancy outcomes in patients with polycystic ovary syndrome(PCOS).Methods 83 patients with PCOS were divided into a control group(40 cases)and an observation group(43 cases)based on whether LMWH was used during freeze-thaw embryo transfer(FET).Endometrial blood flow-related indexes of pulsatility index(PI),resistance index(RI),ratio of end-systolic to end-diastolic blood flow velocity(S/D),pregnancy outcome and adverse reactions were analyzed in the two groups.Results After treatment,the endometrial blood flow PI,RI and S/D of the observation group were lower than those of the control group,and the embryo implantation rate as 66.23%was higher than that of the control group as 48.61%,with a statistically significant difference(P<0.05);the rate of early miscarriage was lower than that of the control group as 5.71%,which was lower than that of the control group as 28.57%(P<0.05);the comparison of the rates of clinical pregnancy and the incidence of adverse reactions of the two groups did not have a statistically significant difference(P>0.05).Conclusion Application of LMWH therapy in frozen-thawed embryo cycles improves uterine arterial blood flow,increases embryo implantation rates,and improves pregnancy outcomes in patients with PCOS.
关键词
多囊卵巢综合征/低分子肝素/冻融胚胎周期/妊娠结局Key words
polycystic ovary syndrome/low-molecular-weight heparin/frozen-thawed embryo cycles/pregnancy outcome引用本文复制引用
基金项目
江西省卫生健康委科技计划项目(202212116)
出版年
2024
NETL
NSTL
万方数据