吲哚布芬联合氯吡格雷对冠心病患者的治疗效果
Therapeutic effect of indobufen combined with clopidogrel on patients with coronary heart disease
李佳 1刘晓宁 2张海龙3
作者信息
- 1. 开封市人民医院心血管内科,开封 475000
- 2. 开封市中医院心病科,开封 475000
- 3. 河南大学基础医学院免疫学教研室,开封 475000
- 折叠
摘要
目的 探讨吲哚布芬结合常规抗血小板治疗冠心病的效果及其对主要心血管不良事件(MACE)的作用.方法 选取110 例冠心病患者,采用随机数字表法将其分为两组.对照组 55 例,采用阿司匹林+氯吡格雷治疗,观察组 55 例,采用吲哚布芬片+氯吡格雷治疗,比较两组血小板功能、凝血功能、心功能改善及预后情况.结果 治疗后,观察组环氧化酶-2(COX-2)、血小板活化因子(PAF)、β-凝血球蛋白(β-TG)均低于对照组,差异有统计学意义(P<0.05);活化部分凝血酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)均长于对照组(P<0.05):左心室射血分数(LVEF)高于对照组,左心室舒张的末期内径(LVDD)低于对照组(P<0.05);观察组的MACE发生率以及药物相关不良反应发生率均低于对照组(P<0.05).结论 与阿司匹林+氯吡格雷的常规抗血小板治疗相比,采用吲哚布芬片+氯吡格雷治疗能增强血小板功能,改善心功能,降低MACE发生风险与不良反应.
Abstract
Objective To observe the application value of indobufen tablets combined with routine antiplatelet therapy in the prevention and treatment of major adverse cardiovascular events(MACE)in coronary heart disease.Methods 110 patients with coronary heart disease were selected and randomly divided into two groups,with 55 cases in each group.The control group were treated with aspirin and clopidogrel,while the observation group were treated with indobufen tablets and clopidogrel.The improvement and prognosis of platelet function,coagulation function,and heart function were compared between the two groups of patients.Results After treatment,the COX-2,PAF,and β-TG levels were lower than those in the control group(P<0.05).APTT,PT,TT were all higher than the control group(P<0.05).LVEF was higher than the control group,and LVDD was lower than the control group(P<0.05).The incidence of MACE and drug-related side effects in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with conventional antiplatelet therapy with aspirin and clopidogrel,treatment with indobufen tablets and clopidogrel can enhance platelet function and prolong clotting time.It has a positive significance in improving patient cardiac function,reducing the risk of MACE and drug-related side effects.
关键词
冠心病/吲哚布芬片/血小板功能/凝血功能/氯吡格雷Key words
coronary heart disease/indobufen tablets/platelet function/coagulation function/clopidogrel引用本文复制引用
基金项目
河南省医学科技攻关项目(SBGJ202102196)
出版年
2024
NETL
NSTL
万方数据