Analysis of risk factors of COVID-19 infection in patients with type 2 diabetes mellitus
Objective To investigate the risk factors of corona virus disease 2019(COVID-19)infection in patients with type 2 diabetes mellitus(T2DM).Methods 78 T2DM patients without COVID-19 and 24 T2DM patients with COVID-19 were selected.Age,body mass index,duration of diabetes,systolic blood pressure,diastolic blood pressure,blood lipids,white blood cell count,neutrophil count,fasting glucose,2 h postprandial glucose,fasting C-peptide,2 h postprandial C-peptide,glycated hemoglobin,and β-hydroxybutyrate were compared,and the correlations between the above factors and COVID-19 infection were analyzed.Results The level of total cholesterol in the infected group was significantly lower than that in the uninfected group.The difference was statistically significant(P<0.05).The levels of HbA1c and β-hydroxybutyric acid in T2DM patients with COVID-19 were significantly higher than those in T2DM patients without COVID-19(P<0.05).Spearman correlation analysis showed that COVID-19 infection was positively correlated with fasting glucose,glycated hemoglobin,systolic blood pressure,and β-hydroxybutyrate(P<0.05)and COVID-19 infection was negatively correlated with total cholesterol and postprandial 2 h C-peptide(P<0.05).Logistic regression analysis revealed that total cholesterol and glycated hemoglobin were important influencing factors of T2DM patients with COVID-19 infection(P<0.05).Conclusion Elevated fasting glucose,glycated hemoglobin,systolic blood pressure,and β-hydroxybutyrate levels,as well as decreased total cholesterol and 2 h postprandial C-peptide levels,may be risk factors for the infection of COVID-19 in patients with T2DM,and control of related factors can reduce the risk of COVID-19 infection in patients with T2DM.
type 2 diabetes mellituscorona virus disease 2019risk factor
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