Expression level of miR-150-5p of thyroid cancer patients and its relationship with clinical pathological characteristics
Objective To investigate the expression level of miR-150-5p in tissues and serum of thyroid cancer tissues and to explore its auxiliary value for differential diagnosis of thyroid cancer.Methods 82 cases of thyroid cancer patients were selected(pathology group),and 82 cases of healthy people with physical examination were selected and set as the control group.The miR-150-5p expressions in the tissue and serum of thyroid cancer patients were compared,and the relationship between the miR-150-5p expressions in tissue and serum and the clinical characteristics of thyroid cancer patients was analyzed.Results The miR-150-5p expression level in thyroid cancer tissues was lower than that in paraneoplastic tissues,showing a statistically significant difference(P<0.05).Serum miR-150-5p level in the case group was lower than that in the control group(P<0.05).Comparison of tissue and serum miR-150-5p expression levels in patients with different clinical stages,differentiation degrees,lymph node metastasis,and tumor diameter conditions showed statistically significant differences(P<0.05).Tissue miR-150-5p expression was significant negative correlation(P<0.05)with clinical stage(rs=-0.497),lymph node metastasis(rs=-0.315),and tumor diameter(rs=-0.444).The miR-150-5p expression was significant positive correlation(P<0.05)with differentiation degree(r=0.404).Serum miR-150-5p expression was significant negative correlation(P<0.05)with clinical stage(rs=-0.455),lymph node metastasis(rs=-0.306),and tumor diameter(rs=-0.433).The miR-150-5p expression was significant positive correlation(P<0.05)with degree of differentiation(rs=0.420).Conclusion The miR-150-5p shows low expression in tissue and serum of thyroid cancer,which is closely correlated with clinical stage,degree of differentiation,lymph node metastasis,and tumor diameter.
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