Advances in the study of B4GALT1 in malignant tumours
β1,4 galactosyltransferase 1(B4GALT1)is a member of the β1,4 galactosyltransferase family,and its main biological function is to transfer galactose from uridine diphosphate galactose to terminal β-N-acetylglucosamine residues on the Golgi and to catalyze the formation of glycoconjugates.As a transmembrane protein distributed on the cell membrane,B4GALT1 is also involved in biological processes such as cell adhesion,immune response,and embryo implantation,and plays an important role in physiological processes such as angiogenesis and apoptosis.Abnormal expression of B4GALT1 is associated with the clinical progression of many malignant tumors and plays a key role in carcinogenesis.This article mainly reviews the recent progress of the relevant biological functions of B4GALT1 in malignant tumors and its mechanism of expression regulation,which provids a theoretical basis for the prevention and treatment of malignant tumors.
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