Discussion about the molecular targets and mechanism of Ziziphus jujuba in anti-atherosclerosis
Objective To analyze the active components,molecular targets,and mechanism of anti-atherosclerosis(AS)of Ziziphus jujuba by network pharmacology and molecular docking methods.Methods The active components of Ziziphus jujuba and their targets were identified by TCMSP database.Disease-related targets of AS were obtained from GeneCards,OMIM,TTD,pharmgKB,DrugBank and DisGeNET databases.The PPI network analysis was conducted by intersecting the two sets of targets to identify the key targets.Pathway enrichment analysis was performed to construct a network representing the"active components-core target-signal pathway"of Ziziphus jujuba.Finally,the core effective components and their targets were verified by molecular docking.Results A total of 9 active components and 268 common pharmacological targets were identified.GO analysis yielded 2 180 biological pathways,while KEGG analysis identified 159 signaling pathways.Among these,the AS-related pathways mainly involved PI3K/AKT,lipid and atherosclerosis,MAPK and so on.Molecular docking results demonstrated strong binding ability of active components such as Jujuboside A,Zizyphusine and Sanjoinenine with core targets including MAPK1,MAPK3,PIK3CA,PIK3CB,and AKT1.Conclusion Ziziphus jujuba may play a role in the treatment of AS by acting on the molecular targets,including MAPK1,MAPK3,PIK3CA,PIK3CB,and AKT1,through active components such as Jujuboside A,Zizyphusine,and Sanjoinenine.Furthermore,this regulation influences agains AS related pathways associated with PI3K/AKT,lipids and atherosclerosis,MAPK,and so on.
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