华夏医学2024,Vol.37Issue(4) :63-69.DOI:10.19296/j.cnki.1008-2409.2024-04-009

经皮导入复方甘草酸苷溶液对玫瑰痤疮的临床治疗效果

Clinical effects of percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of acne rosacea

易江 杨凤元 黄熙 严文杰
华夏医学2024,Vol.37Issue(4) :63-69.DOI:10.19296/j.cnki.1008-2409.2024-04-009

经皮导入复方甘草酸苷溶液对玫瑰痤疮的临床治疗效果

Clinical effects of percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of acne rosacea

易江 1杨凤元 1黄熙 1严文杰1
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作者信息

  • 1. 桂林医学院附属医院皮肤科,桂林 541001
  • 折叠

摘要

目的 评估经皮导入复方甘草酸苷溶液治疗红斑毛细血管扩张型玫瑰痤疮的临床效果和安全性.方法 将75 例红斑毛细血管扩张型玫瑰痤疮患者随机分为3 组,治疗A组27 例患者予以经皮导入复方甘草酸苷溶液联合外用医用冷敷敷料,治疗B组25 例患者予以口服复方甘草酸苷片联合外用医用冷敷敷料,对照组 23例患者仅外用医用冷敷敷料.3 组患者的治疗周期均为 4 周.结果 治疗结束后,3 组疗效比较,差异具有统计学意义(P<0.05).治疗A组在试验过程中有2 例出现症状一过性加重,予以脱落试验.在 3 组患者的整个治疗过程中,未出现严重不良反应.在治疗结束后 1 个月的随访中,3 组复发率比较,差异无统计学意义(P>0.05).结论 经皮导入复方甘草酸苷溶液治疗红斑毛细血管扩张型玫瑰痤疮在临床上安全有效.

Abstract

Objective To evaluate the clinical efects and safety of percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of erythema telangiectasia acne rosacea.Methods 75 patients with erythema telangiectasia rose acne were randomly divided into 3 groups.Group A(27 cases)were treated with compound ammonium glycyrrhizin solution combined with external medical cold dressing.Group B(25 cases)were treated with oral compound ammonium glycyrrhizin tablets combined with external medical cold dressing,and the control group(23 cases)were treated with external medical cold dressing only.The treatment cycle of the 3 groups was 4 weeks.Results After treatment,the efficacy of the 3 groups was compared,and the difference was statistically significant(P<0.05).During the trial,2 cases in Group A were experienced transient worsening of symptoms and were subjected to dropout testing.Throughout the treatment process of the three groups of patients,no serious adverse reactions occurred.During the one month follow-up after treatment,there was no statistically significant difference in recurrence rates among the three groups(P>0.05).Conclusion Percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of erythema telangiectasia rose acne is clinically safe and effective.

关键词

经皮导入/复方甘草酸苷/玫瑰痤疮

Key words

percutaneous introduction/compound ammonium glycyrrhizin/acne rosacea

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基金项目

2021年广西药品安全科研项目()

广西肝脏损伤与修复分子医学重点实验室课题(GXLIRMMKL-K202203)

2022年桂林市科技计划项目(市科[2023]11号)

出版年

2024
华夏医学
桂林医学院

华夏医学

影响因子:0.569
ISSN:1008-2409
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