首页|经皮导入复方甘草酸苷溶液对玫瑰痤疮的临床治疗效果

经皮导入复方甘草酸苷溶液对玫瑰痤疮的临床治疗效果

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目的 评估经皮导入复方甘草酸苷溶液治疗红斑毛细血管扩张型玫瑰痤疮的临床效果和安全性。方法 将75 例红斑毛细血管扩张型玫瑰痤疮患者随机分为3 组,治疗A组27 例患者予以经皮导入复方甘草酸苷溶液联合外用医用冷敷敷料,治疗B组25 例患者予以口服复方甘草酸苷片联合外用医用冷敷敷料,对照组 23例患者仅外用医用冷敷敷料。3 组患者的治疗周期均为 4 周。结果 治疗结束后,3 组疗效比较,差异具有统计学意义(P<0。05)。治疗A组在试验过程中有2 例出现症状一过性加重,予以脱落试验。在 3 组患者的整个治疗过程中,未出现严重不良反应。在治疗结束后 1 个月的随访中,3 组复发率比较,差异无统计学意义(P>0。05)。结论 经皮导入复方甘草酸苷溶液治疗红斑毛细血管扩张型玫瑰痤疮在临床上安全有效。
Clinical effects of percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of acne rosacea
Objective To evaluate the clinical efects and safety of percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of erythema telangiectasia acne rosacea.Methods 75 patients with erythema telangiectasia rose acne were randomly divided into 3 groups.Group A(27 cases)were treated with compound ammonium glycyrrhizin solution combined with external medical cold dressing.Group B(25 cases)were treated with oral compound ammonium glycyrrhizin tablets combined with external medical cold dressing,and the control group(23 cases)were treated with external medical cold dressing only.The treatment cycle of the 3 groups was 4 weeks.Results After treatment,the efficacy of the 3 groups was compared,and the difference was statistically significant(P<0.05).During the trial,2 cases in Group A were experienced transient worsening of symptoms and were subjected to dropout testing.Throughout the treatment process of the three groups of patients,no serious adverse reactions occurred.During the one month follow-up after treatment,there was no statistically significant difference in recurrence rates among the three groups(P>0.05).Conclusion Percutaneous introduction of compound ammonium glycyrrhizin solution in the treatment of erythema telangiectasia rose acne is clinically safe and effective.

percutaneous introductioncompound ammonium glycyrrhizinacne rosacea

易江、杨凤元、黄熙、严文杰

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桂林医学院附属医院皮肤科,桂林 541001

经皮导入 复方甘草酸苷 玫瑰痤疮

2021年广西药品安全科研项目广西肝脏损伤与修复分子医学重点实验室课题2022年桂林市科技计划项目

GXLIRMMKL-K202203市科[2023]11号

2024

华夏医学
桂林医学院

华夏医学

影响因子:0.569
ISSN:1008-2409
年,卷(期):2024.37(4)