Effects of amitriptyline in the treatment of irritable bowel syndrome
Objective To observe the clinical efficacy of amitriptyline in the treatment of irritable bowel syndrome(IBS).Methods 110 IBS patients were selected as the study subjects.They were randomly divided into two groups using a random number table method,with 55 patients in each group.The control group were received adjuvant treatment with conventional dose of amitriptyline,while the experimental group were received low-dose amitriptyline as an adjuvant therapy.The treatment efficacy and safety were compared between two groups of patients.Results At different drug doses,the symptom scores of upper abdominal pain,abdominal burning,and decreased appetite in the experimental group were slightly higher than those in the control group,and there was no statistically significant difference(P>0.05),while the levels of gastrin(GAS),motilin(MLT),pepsin Ⅰ(PG Ⅰ),and pepsin Ⅱ(PG Ⅱ)were slightly lower than those in the control group(P>0.05).The slow wave value after meals in the experimental group was slightly lower than that in the control group,and the frequency and percentage of gastric electrical disturbances were slightly higher than those in the control group(P>0.05).The incidence of drug-related adverse reactions in the experimental group was lower than that in the control group,showing a statistically significant difference(P>0.05).Conclusion Amitriptyline can promote the recovery of related symptoms in IBS patients by enhancing gastric motility and improving digestive function,and has a positive impact on improving the parameters of the patient's gastric electrogram.However,compared with conventional doses,low-dose amitriptyline has higher safety.
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