Effects of caffeine citrate injection combined with CPS for injection on lung function in children with NRDS
Objective To investigate the effects of caffeine citrate injection combined with calf pulmonary surfactant(CPS)on tidal respiratory lung function and serum oxidative stress indexes in neonatal respiratory distress syndrome(NRDS).Methods 74 children with NRDS were selected and divided into the control group(treated with CPS)and observation group(treated with caffeine citrate injection combined with CPS)according to the treatment plan.The clinical efficacy,blood gas analysis indicators before and after treatment,tidal respiratory lung function indicators,serum oxidative stress indicators,E-selectin(CD62E)levels,and incidence of complications were compared between two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,showing a statistically significant difference(P<0.05).After 7 d of treatment,PaO2 and PaCO2 in observation group were higher than those in the control group(P<0.05).After 7 d of treatment,the observation group had a higher time to peak tidal expiratory flow as a proportion of expiratory time(TPTEF/TE),tidal volume(VT),and peak volume ratio(VPEF/VE)compared to the control group,while the respiratory rate(RR)was lower than the control group(P<0.05).After 7 d of treatment,the observation group had a higher TPTEF/TE,VT,and peak volume ratio(VPEF/VE)compared to the control group,while the RR was lower than the control group(P<0.05).There was no statistically significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Caffeine citrate combined with CPS can effectively promote the improvement of blood gas analysis indexes,lung function,relieve oxidative stress-inflammation state,improve efficacy and safety in children with NRDS.
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维普
