Objective To observe the clinical value of blood routine and coagulation parameters in IgG4-related disease(IgG4-RD)with osteoporosis.Methods 26 patients diagnosed with IgG4-RD and 51 healthy controls were selected as the IgG4-RD group and control group,respectively.Blood routine and coagulation tests were performed and analyzed for both groups.26 IgG4-RD patients were further divided into the osteoporosis groups(5 cases)and non osteoporosis groups(21 cases)for blood routine and coagulation tests and analysis.Results The measured values of red blood cell distribution width and white blood cell count,monocyte ratio,immature granulocyte ratio,absolute values of monocytes,absolute values of neutrophils,absolute values of immature granulocytes,measured values of thrombin time,and D-dimer levels in IgG4-RD patients were higher than those in healthy individuals,showing a statistically significant difference(P<0.05).The measured values of red blood cell count,hemoglobin concentration,hematocrit,mean red blood cell volume,mean hemoglobin quantity,mean hemoglobin concentration,platelet volume distribution width,as well as lymphocyte ratio and eosinophil ratio in IgG4-RD patients were lower than those in healthy individuals(P<0.05).The measured values of red blood cell distribution width and absolute values of nucleated red blood cells in patients with IgG4-RD combined with osteoporosis were higher than those in the non osteoporosis group(P<0.05).Conclusion Multiple indicators in blood routine and coagulation function have changed in patients with IgG4-RD,indicating the presence of immune dysfunction,which may serve as a diagnostic and therapeutic basis for IgG4-RD and IgG4-associated osteoporosis.
IgG4-related diseasesosteoporosisblood test indicatorsclinical value
万方数据
维普
