Study on the correlation between trimethylamine oxide and gut microbiota and prognosis in patients with heart failure
Objective To analyze the correlation between trimethylamine oxide(TMAO)and gut microbiota and prognosis in patients with heart failure.Methods Selecting clinical data from 122 patients with heart failure,42 patients with with TMAO≥2.58 μmol/L were classified as the high-level group,80 patients with TMAO<2.58 μmol/L were classified as the low-level group.The results of gut microbiota detection between the two groups were compared,and the correlation between TMAO levels and gut microbiota related parameters was analyzed,statistically analyze the occurrence of adverse prognosis in enrolled patients,compare the differences in TMAO and gut microbiota parameters between the two groups,and verify the predictive efficacy of TMAO for adverse prognosis in heart failure patients.Results The richness of gut microbiota(Chao index),diversity of gut microbiota(Shannon index),clustering values of operational taxonomic units(OTUs)of gut microbiota,and concentrations of Klebsiella and Brucella in the high-level group were all lower than those in the low-level group.The concentrations of Salmonella,Shigella,and Candida were all higher than those in the low-level group,showing a statistically significant difference(P<0.05).TMAO is positively correlated with the concentrations of Salmonella,Shigella,and Candida,but negatively correlated with the concentrations of Chao index,Shannon index,OTUs,Corinthia,and Brucella(P<0.05).TMAO levels have a high predictive power for poor prognosis of heart failure(ACU>0.85).Conclusion There is a certain correlation between TMAO levels and gut microbiota and prognosis in patients with heart failure,and the higher the TMAO level,the higher the incidence of adverse prognosis in patients.
万方数据
维普
