Relationship between CTRP3 and bone metabolism in T2DM and the predictive efficacy of fracture risk
Objective To analyze the relationship between C1q tumor necrosis factor related protein 3(CTRP3)and the level of bone metabolism and to analyze the predictive efficacy of CTRP3 for fracture risk in type 2 diabetes mellitus(T2DM)patients.Methods 121 T2DM patients were selected.The patients were divided into the low CTRP3 level group(CTRP3<300 ng/mL,63 cases)and the high level group(CTRP3≥300 ng/mL,58 cases).The relationship between CTRP3 level and bone metabolism indicators was analyzed.The risk factors of T2DM fractures were analyzed and the predictive efficacy of CTRP3 on fracture risk was verified.Results The bone density,the level of osteoprotegerin(OPG)and bone specific alkaline phosphatase(BALP)in the low CTRP3 level group were significantly lower than those in the high CTRP3 level group(P<0.05).The levels of type 1 collagen at the C-terminus β Special sequence(β-CTX)in the low CTRP3 level group was significantly higher than that in the high CTRP3 level group(P<0.05).The expression of CTRP3 was positively correlated with bone density,the level of OPG was negatively correlated with the level of BALP and β-CTX.The levels of CTRP3,OPG and BALP and bone density in the fracture group were significantly lower than those in the non fracture group,the levels of β-CTX in the fracture group was significantly higher than that in the non fracture group(P<0.05).CTRP3,bone density,OPG,BALP β-CTX were the risk factor for fractures in T2DM patients.CTRP3 had a high predictive efficacy for fracture risk in T2DM patients.Conclusion CTRP3 is closely related to the bone metabolism level in T2DM patients,and CTRP3 expression levels can early predict the fracture risk.
type 2 diabetes mellitusbone metabolismC1q tumor necrosis factor related protein 3fracturepredictive performance
万方数据
维普
