Predictive value of combined diagnosis of PLT,IGFBP-3 and ALB for upper gastrointestinal bleeding in patients with cirrhosis
Objective To explore the predictive value of serum platelet count(PLT),insulin-like growth factor binding protein-3(IGFBP-3)and albumin(ALB)levels for upper gastrointestinal bleeding(UGH)in patients with cirrhosis.Methods 136 patients with cirrhosis were selected and divided into the bleeding group(43 cases)and non-bleeding group(93 cases)based on the presence or absence of UGH after treatment.The levels of serum PLT,IGFBP-3 and ALB were compared between the two groups of patients with different grades of cirrhosis,and the correlation and predictive value were analyzed.Results The levels of PLT,ALB and type IV collagen in the hemorrhagic group were lower than those in the non-hemorrhagic group,while the levels of serum IGFBP-3 and laminin and hyaluronic acid were higher than those in the non-hemorrhagic group,showing a statistically significant difference(P<0.05).Comparing the levels of serum PLT,ALB and type IV collagen in different Child-Pugh grades(A,B and C)in the hemorrhagic group showed that A grade>B grade>C grade,serum IGFBP-3 level,laminin while hyaluronic acid showed that C grade>B grade>A grade(P<0.05).Laminin,hyaluronic acid,and Child-Pugh grade were negatively correlated with serum PLT,ALB and and positively correlated with serum IGFBP-3.The level of type IV collagen is positively correlated with serum PLT and ALB,and negatively correlated with serum IGFBP-3(P<0.05).The AUC of the combined prediction of serum PLT,IGFBP-3 and ALB levels was greater than that of each individual indicator.Conclusion The combined prediction of serum PLT,IGFBP-3 and ALB levels provides a reliable basis for clinical evaluation of UGH in patients with cirrhosis.
万方数据
维普
