Objective To investigate the clinical effects of modified electric convulsive therapy(MECT)combined with paliperidone in the bipolar affective disorder(BPD)patients with manic episodes.Methods 99 patients with BPD manic episodes admitted from May 2021 to May 2023 were collected and divided into drug group(n=49)and MECT combined group(n=50)according to different treatment regiments.The clinical efficacy,control of bipolar disorder and mania,inflammatory factors,neurotransmitters and adverse reactions were compared between the two groups.Results After treatment,the total effective rate in MECT combined group was higher than that in drug group,showing a statistically significant difference(P<0.05).After treatment,the clinical global impression-BP(CGI-BP)score,Bech-rafaelsen mania rating scale(BRMS)score,serum levels of tumor necrosis factor(TNF)-α,interleukin(IL)-1,IL-1β and adrenocorticotrophic hormone(ACTH)in MECT combined group were lower than those in drug group.The serum levels of brain derived neurotrophic factor(BDNF)and glial derived neurotrophic growth factor(GDNF)in MECT combined group were higher than those in drug group(P<0.05).The incidence of adverse reactions had no significant difference between the drug group and MECT combined group(P>0.05).Conclusion MECT combined with paliperidone has good clinical efficacy in the treatment of BPD patients with manic episodes,which improves neurotransmitter,reduces inflammatory factors,helps to control manic state and improves the condition of bipolar disorder.
关键词
双相情感障碍/狂躁发作/改良无抽搐电休克疗法/帕利哌酮
Key words
bipolar affective disorder/manic episodes/modified electric convulsive therapy/paliperidone
维普
万方数据