Therapeutic effects of aminophylline combined with terbutaline and salbutamol in the elderly patients with bronchial asthma
Objective To investigate the effects of aminophylline injection combined with terbutaline and salbutamol in the elderly patients with bronchial asthma(BA).Methods 86 elderly patients with BA were randomly divided into the conventional group and combined group,with 43 cases in each group.The patients in the conventional group were treated with terbutaline and salbutamol inhalation,and the patients in the combined group were treated with aminophylline on the basis of the conventional group.The clinical efficacy,disappearance time of clinical symptoms,lung function,asthma control,airway inflammatory factors,immune function,adverse reactions and recurrence were compared the between conventional group and combined group.Results After treatment,the total effective rate in combined group was 93.02%,which was higher than 76.74%in conventional group,showing a statistically significant difference(P<0.05).The disappearance time of asthma,wheezing sound and cough in combined group were shorter than those in conventional group(P<0.05).FEV1,PEF,FEV1/FVC,ACT scores,IgA,IgG and IgM in combined group were obviously higher than those in conventional group,and the levels of phlegm and peripheral blood eosinophil(EOS),IL-17,TGF-0 and IgE in sputum in combined group were obviously lower than those in conventional group(P<0.05).During treatment,the overall incidence of adverse reactions was not different between the conventional group and combined group(P>0.05).After 6 months of follow-up,the recurrence rate in the combined group was obviously lower than that in conventional group(P<0.05).Conclusion Aminophylline combined with salbutamol and terbutaline has definite clinical efficacy in the elderly patients with BA,which controls effectively the progression of asthma,improves lung function,reduces the degree of airway inflammation,corrects immune dysfunction,and reduces the recurrence rate.
万方数据
维普
