Objective To observe the application effects of preoperative atropine pretreatment in anesthesia for endometrial cancer surgery.Methods 115 patients with endometrial cancer were selected and randomly divided into two groups.57 cases in the control group were received preoperative dexmedetomidine assisted general anesthesia.58 cases in the observation group were received preoperative atropine combined with dexmedetomidine as an auxiliary general anesthesia.The changes in basic physical signs,preoperative and postoperative cognitive function scores,delirium occurrence,and postoperative recovery during the perioperative period were compared between two groups patients.Results After anesthesia,the HR and MAP in the observation group at T1 and T0,T2 and T0,T3 and T0 were significantly lower than those in the control group,showing a statistically significant difference(P<0.05).The MMSE and MoCA scores at T3,as well as the incidence of delirium at 1 h,24 h,and 72 h after extubation,and there was no statistically significant difference compared to the control group(P>0.05).The postoperative recovery time,PACU retention time,and RSS score in the observation group were significantly lower than those on the control group(P<0.05).Conclusion Pre operative atropine pretreatment avoids fluctuations in perioperative signs in patients with endometrial cancer,and improves awakening quality without affecting postoperative cognition or increasing anesthesia risk.
维普
万方数据