Progress of prostaglandin receptor EP3 in ischemia-reperfusion injury
Ischemia-reperfusion injury(IRI)is often secondary to pathological processes such as myocardial infarction,ischemic stroke and acute kidney injury,and can also appear in clinical treatment,such as thrombolytic therapy,percutaneous coronary intervention,organ transplantation,etc.Consequently,preventing and treating IRI remains a significant challenge in clinical practice.The EP3 receptor regulates cellular functions through various pathways,including oxidative stress,inflammatory responses and apoptosis,and it plays an important role in IRI.Thus,receptor EP3 may represent a promising new therapeutic target for IRI.This article analyzes and reviews the role and possible mechanisms of EP3 receptor in IRI from the perspectives of myocardial IRI,cerebral IRI and ischemic kidney injury,aiming to provide a theoretical basis for the clinical treatment of ischemia-reperfusion injury.
万方数据
维普
