Glycolipid metabolic disorders(GLMD)is a complex metabolic disorder characterized by abnormal metabolism of sugars and lipids,often accompanied by damage to multiple target organs.With the global GLMD incidence rate rising year by year,the need for early and effective intervention is also increasingly prominent.Apolipoprotein E(APOE)plays a crucial role in lipid metabolism and is closely related to the occurrence and development of GLMD.This article aims to explore the pathogenesis of GLMD in depth,with a particular focus on the genetic basis of APOE gene polymorphism.It elaborates on the intrinsic relationship and mechanism between APOE gene polymorphism and GLMD,and further explores how to use this relationship to predict and diagnose GLMD.The goal is to provide a more comprehensive and in-depth understanding for the prevention,diagnosis,and treatment of GLMD.
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