METTL3 expression and prognostic value analysis in non-small cell lung cancer by IHC combined with database
Objective To investigate the expression of methyltransferase-like 3(METTL3)in non-small cell lung cancer and its relationship with clinicopathological parameters and prognosis.Methods Based on IHC detection and multi-source database,the expression level of METTL3 in NSCLC and its relationship with clinicopathological parameters and prognosis were analyzed in this study.Results METTL3 was generally expressed in NSCLC,and it is closely related to tumor N typing and TNM staging(P<0.05).The overall survival(OS)and disease-free survival(DFS)of NSCLC patients with high expression of METTL3 were significantly shorter than those with low expression METTL3 and the difference was statistically significant(P<0.001).Accoding to the survival analysis of different clinical grading indexes,it was found that the high expression of METTL3 was significantly related to the shortened survival time of TNM Ⅰ,TNM Ⅱ and patients without lymph node maetastasis(NO)(P<0.05).Multivariate Cox regression analysis showed that the high expression of METTL3 was an independent predictor of poor prognosis in NSCLC patients(P<0.05).Conclusion The high expression of METTL3 promotes the occurrence and development of NSCLC,and increases the risk of poor prognosis of patients(especially in the early stage).METTL3 has the potential as a prognostic and therapeutic target for NSCLC.
万方数据
维普
