Relationship between the expression of CXCL3 and TLRs9 in serum and postoperative recurrence and metastasis of breast cancer
Objective To analyze the relationship between serum CXC recombinant chemokine ligand 3(CXCL3),Toll-like receptors 9(TLR9),and postoperative recurrence and metastasis of breast cancer.Methods 105 breast cancer patients were underwent breast-conserving surgery.Differences in the serum levels of tumor markers,serum CXCL3 mRNA,and TLs9 mRNA before and after treatment were compared.The correlation between CXCL3 mRNA and TLR9 mRNA and the severity of breast cancer was tested using the Spearman correlation coefficient.The predictive value of CXCL3 and TLR9 mRNA for recurrence or metastasis after surgery was verified by drawing the receiver operating characteristic(ROC)curve.Results Post-surgery,patients had lower levels of CEA,CA153,CA199,CXCL3,and TLR9 compared to preoperative levels,showing a statistically significant difference(P<0.05).The mRNA levels of CXCL3 and TLR9 were positively correlated with CEA,CA153,and CA199(P<0.05).The relative expression levels of CXCL3 and TLR9 mRNA,along with CEA,CA153,and CA199 in the recurrence and metastasis group,were higher than those in the non-recurrence and metastasis group(P<0.05).The ROC curve analysis showed that the sensitivity and specificity of CXCL3 mRNA in predicting postoperative recurrence and metastasis of breast cancer were 85.25%and 79.66%,respectively,and the cut-off value was 0.85.The sensitivity and specificity of TLRs 9 mRNA in predicting postoperative recurrence and metastasis of breast cahcer were 82.72%and 75.49%,respectively,and the cut-off value was 10.71(AUC>0.85).Conclusion Monitoring changes in serum levels of CXCL3 and TLR9 may enable early prediction of postoperative disease recurrence and metastasis risk in breast cancer patients.
breast cancerpostoperative metastasis and recurrenceCXC chemokine ligand 3Toll like receptor 9predictive value
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维普
