Randomized controlled study of alfentanil combined with nalbuphine for esophageal cancer surgery
Objective To investigate the anesthetic effect of alfentanil combined with nalbuphine in radical resection for esophageal cancer.Methods 94 patients were selected and randomly divided into Group A and Group B by random number table method,with 47 cases in each group.Group A were induced with alfentanil and nalbuphine,while Group B were induced with remifentanil and nalbuphine.The anesthesia indexes,visual analogue scale(VAS)scores and Ramasy scores were compared between the two groups.Results The amount of propofol used in Group A was less than that in Group B,showing a statistically significant difference(P<0.05).The fluctuation amplitude of heart rate,systolic blood pressure,diastolic blood pressure,Cor,Ne,and CAT levels during T1-T3 in Group A was smaller than that in Group B(P<0.05).The VAS scores and Ramasy scores of Group A were lower than those of Group B at 12 h,18 h,and 24 h after surgery(P<0.05).There was no significant difference in the recovery time,onset time of anesthesia,and PACU recovery time between the two groups(P>0.05).Conclusion The combination of alfentanil and nalbuphine can reduce the amount of anesthetic drugs used during radical resection of esophageal cancer,stabilize hemodynamics,alleviate stress response,and reduce postoperative pain and agitation.
alfentanilnabufineradical resection of esophageal cancerhemodynamicsstress response
万方数据
维普
