摘要
目的 探讨阿芬太尼联合纳布啡用于食管癌根治术的麻醉效果.方法 选取拟行食管癌根治术患者 94例,以随机数字表法分为A组、B组,各47 例.其中A组采用阿芬太尼联合纳布啡麻醉诱导,B组采用瑞芬太尼联合纳布啡麻醉诱导.检测并对比两组麻醉各项指标及视觉模拟评分(VAS)评分、Ramasy评分.结果 A组丙泊酚用量少于B组,差异有统计学意义(P<0.05);A组T1-T3 时的心率、收缩压、舒张压、Cor、Ne、CAT水平波动幅度小于B组(P<0.05);A组术后12、18、24 h的VAS评分和Ramasy评分低于B组(P<0.05);两组苏醒时间、麻醉起效时间、PACU恢复时间比较无明显差异(P>0.05).结论 阿芬太尼联合纳布啡可减少食管癌根治术患者术中麻醉药物用量、稳定血流动力学、减轻应激反应、降低术后疼痛及躁动程度.
Abstract
Objective To investigate the anesthetic effect of alfentanil combined with nalbuphine in radical resection for esophageal cancer.Methods 94 patients were selected and randomly divided into Group A and Group B by random number table method,with 47 cases in each group.Group A were induced with alfentanil and nalbuphine,while Group B were induced with remifentanil and nalbuphine.The anesthesia indexes,visual analogue scale(VAS)scores and Ramasy scores were compared between the two groups.Results The amount of propofol used in Group A was less than that in Group B,showing a statistically significant difference(P<0.05).The fluctuation amplitude of heart rate,systolic blood pressure,diastolic blood pressure,Cor,Ne,and CAT levels during T1-T3 in Group A was smaller than that in Group B(P<0.05).The VAS scores and Ramasy scores of Group A were lower than those of Group B at 12 h,18 h,and 24 h after surgery(P<0.05).There was no significant difference in the recovery time,onset time of anesthesia,and PACU recovery time between the two groups(P>0.05).Conclusion The combination of alfentanil and nalbuphine can reduce the amount of anesthetic drugs used during radical resection of esophageal cancer,stabilize hemodynamics,alleviate stress response,and reduce postoperative pain and agitation.
维普
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