Predictive value of serum HMGB1 and NF-κB for postoperative pulmonary infection risk in patients with chronic subdural hematoma
Objective To analyze the predictive value of serum high mobility group box-1 protein(HMGB1)and nuclear factor kappa-B(NF-κB)for the risk of postoperative pulmonary infection in patients with chronic subdural hematoma(CSDH).Methods 115 CSDH patients underwent modified intracranial drilling and drainage surgery.Patients were categorized based on the occurrence of postoperative pulmonary infection into the infected group(25 cases)and uninfected group(90 cases).General and clinical data were collected from both groups,and risk factors for postoperative pulmonary infection in CSDH patients were identified through univariate and logistic regression analysis.receiver operating characteristic(ROC)curves were used to validate the predictive value of serum HMGB1 and NF-κB.Results Risk factors for postoperative pulmonary infection included diabetes,underlying lung diseases,tracheotomy during operation,mechanical ventilation for≥7 d,postoperative nasogastric tube enteral nutrition support,ALB<30 g/L,HMGB1≥80 mg/L,and NF-κB≥40 pg/mL.The sensitivity and specificity of serum HMGB1 were 83.31%and 79.48%,respectively,and for NF-κB,they were 80.25%and 76.32%,respectively(AUC>0.85).Conclusion Regular monitoring of serum indicators such as HMGB1 and NF-κB can facilitate the early prediction of postoperative pulmonary infection to a certain extent.
chronic subdural hematomaimproved intracranial drilling and drainage surgerypostoperative pulmonary infectionhigh mobility group box-1 proteinnuclear factor kappa-B
万方数据
维普
