摘要
目的 探讨单唾液酸四己糖神经节苷脂钠(MGS)联合多巴丝肼治疗血管性帕金森综合征(VP)患者的疗效及其应用价值.方法 选取80 例VP患者开展回顾性研究,依据治疗方案分为对照组40 例(多巴丝肼)、观察组40 例(MGS联合多巴丝肼).对比两组临床疗效及治疗前后帕金森评定第二、三分量表(UPDRS Ⅱ、UPDRS Ⅲ)、帕金森病生存质量调查问卷(PDQ-39)评分、神经递质[神经丝蛋白轻链(sNFL)、β-淀粉样前体蛋白(β-APP)、5-羟色胺(5-HT)]、微炎症状态[载脂蛋白A1、白细胞介素-32(IL-32)、同型半胱氨酸(Hcy)、白细胞介素-1(IL-1)].结果 观察组总有效率高于对照组,差异有统计学意义(90.00％比 67.50％,P<0.05);与对照组比较,观察组治疗后UPDRS Ⅱ、UPDRS Ⅲ、PDQ-39 评分降低(P<0.05);与对照组比较,观察组治疗后血清sNFL、IL-32、Hcy、IL-1 水平降低,β-APP、5-HT、载脂蛋白A1 水平升高(P<0.05).结论 MGS联合多巴丝肼治疗VP患者的疗效确切,可改善运动功能,提高生活质量,纠正神经递质紊乱状态,抑制炎症反应.
Abstract
Objective To investigate the curative effect and application value of monosialotetrahexosyl ganglioside sodium(MGS)combined with Levodopa and Benserazide hydrochlo-ride in the patients with vascular Parkinsonism(VP).Methods A retrospective study was conducted in 80 VP patients were divided into the control group(levodopa and benserazide hydrochlo-ride therapy)and the observation group(MGS combined with Levodopa and Benserazide Hydrochlo-ride therapy)according to the treatment plan,with 40 patients in each group.The clinical efficacy of the two groups was compared,as well as the scores of the second and third scales of the Parkinson's disease rating scale(UPDRS Ⅱ,UPDRS Ⅲ),the Parkinson's disease quality of life questionnaire(PDQ-39).The levels of serum neurofilament light chain(sNFL),β-amyloid precursor protein(β-APP),serotonin(5-HT),apolipoprotein A1,interleukin-32(IL-32),homocysteine(Hcy),interleukin-1(IL-1)before and after treatment were compared betwween the two groups.Results The total effective rate in the observation group was significantly higher than that in the control group,with a statistically significant difference(90.00％vs.67.50％,P<0.05).Compared with the control group,the scores of UPDRS Ⅱ,UPDRS Ⅲ,and PDQ-39 in the observation group were significantly decreased after treatment(P<0.05).Compared with the control group,the levels of serum sNFL,IL-32,Hcy,and IL-1 were significantly decreased after treatment in the observation group,while the levels of serum β-APP,5-HT,and apolipoprotein A1 were significantly increased after treatment in the observation group(P<0.05).Conclusion The efficacy of MGS combined with Levodopa and Benserazide hydrochlo-ride in the treatment of VP patients is confirmed,which improves the motor function,enhances the quality of life,corrects the neurotransmitter disorders,and inhibits the inflammatory reactions.
维普
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