Value of carbamazepine in the prevention and treatment of cognitive impairment after subarachnoid hemorrhage
Objective To observe the preventive value of carbamazepine on postoperative cognitive impairment in patients with subarachnoid hemorrhage(SAH).Methods 120 SAH patients were randomly divided into a control group and a carbamazepine treatment group,with 60 patients in each group.Both groups were underwent endovascular coil embolization.The control group were received conventional drug treatment after surgery,while the carbamazepine group were received carbamazepine in addition to conventional treatment.Neurotransmitter levels,serum neurological function indicators,EEG activity,and cognitive status were compared between the two groups.Results The levels of GABA,5-HT,DA,and NE were higher in the carbamazepine group than in the control group,showing a statistically significant difference(P<0.05).The BDNF level in the carbamazepine group was higher,while NF-L,NSE,and S100 β levels were lower(P<0.05).The α wave frequency in the carbamazepine group was higher,whereas the β wave,θ wave,and δ wave frequencies were lower than those in the control group(P<0.05).The incidence of cognitive impairment in the carbamazepine group was 3.33%(2/60),lower than 16.67%(10/60)in the control group,and the MMSE and MoCA scores were higher(P<0.05).Conclusion Carbamazepine can improve neurotransmitter levels and neurological function in SAH patients post-surgery,positively affecting brain electrical activity recovery and reducing cognitive impairment risk.
万方数据
维普
