Application of dexmedetomidine in protecting neurological function in the patients undergoing off-pump coroary artery bypass surgery
Objective To observe the protective effect of dexmedetomidine on neurological function in the patients undergoing off pump coronary artery bypass surgery.Methods 123 patients who underwent off-pump coroary artery bypass grafting were randomly divided into the conventional group(61 cases)and dextrometer group(62 cases).The conventional group were received routine general anesthesia,while the dexmedetomidine group were received dextrometomidine assisted general anesthesia.The cerebral oxygen metabolism,neurological function,cognitive function,and anesthesia safety of the two groups of patients were compared.Results Under different anesthesia regimens,the jugular bulb oxygen saturation(SjvO2)of the dexmedetomidine group was higher than that of the control group,while arterial oxygen content(CaO2),difference in arterial and venous oxygen content[D(a-jv)O2],and cerebral oxygen uptake rate(CEO2)were lower than those of the control group.The differences were statistically significant(P<0.05).The levels of galactin 3(Gal-3),neuropeptide Y(NPY),neuron specific enolase(NSE),and central nervous system specific protein(S100 β)in the dexmedetomidine group were lower than those in the control group(P<0.05).The Mini Mental State Scale(MMSE)and Montreal Cognitive Assessment Scale(MoCA)scores of the dexmedetomidine group were higher than those of the conventional group(P<0.05).There was no statistically significant difference in the incidence of anesthesia related side effects between two groups of patients(P>0.05).Conclusion Dexmedetomidine-assisted general anesthesia can improve cerebral oxygen metabolism,effectively reduce neurological damage,and lessen postoperative cognitive impairment in patients undergoing off-pump coronary artery bypass surgery without increasing the risk of anesthesia-related side effects.
万方数据
维普
