Predictive effect of serum PTX3 and Omentin-1 on adverse pregnancy outcome of gestational diabetes
Objective To analyze the predictive effect of serum PTX3 and Omentin-1 on adverse pregnancy outcomes in gestational diabetes mellitus(GDM).Methods 123 patients with GDM were divided into the mild group(53 cases)and moderate to severe group(70 cases)based on the degree of insulin resistance.The correlations between serum levels of PTX3,Omentin-1,GDM blood glucose,inflammatory response,and insulin sensitivity indicators,and their predictive power for adverse pregnancy outcomes were analyzed.Results Levels of FBG,2-h PG,Hcy,Cycs,NGAL,GAL,and PTX3 were higher in the moderate to severe group than in the mild group,while Omentin-1 levels were lower,showing a statistically singificant difference(P<0.05).Serum PTX3 showed a positive correlation with blood glucose levels,inflammatory markers,and insulin sensitivity markers(P<0.05).Omentin-1 was negatively correlated(P<0.05).The incidence of adverse pregnancy outcomes among the 123 GDM patients was 26.83%(33/123).Serum PTX3 and Omentin-1 had sensitivities of 82.62%and 80.35%,and specificities of 80.41%and 79.33%,respectively(AUC>0.85).Conclusion Serum PTX3 is positively correlated with the progression of GDM,while Omentin-1 is negatively correlated.Both biomarkers are promising for predicting adverse pregnancy outcomes in GDM.
gestational diabetes mellituspentameric protein 3retinolin-1 and insulin resistanceadverse pregnancy outcomes
万方数据
维普
