摘要
目的 分析血清正五聚蛋白 3(PTX3)、网膜素-1(Omentin-1)对妊娠期糖尿病(GDM)患者不良妊娠结局的预测效能.方法 选取123 例GDM患者,根据胰岛素抵抗程度不同分为轻度组53 例,中重度组70 例,分析血清PTX3、Omentin-1 与GDM患者血糖、炎症反应、胰岛素敏感性指标的相关性及对其不良妊娠结局的预测效能.结果 中重度组的FBG、2 h PG、Hcy、Cycs、NGAL、GAL、PTX3 均高于轻度组,Omentin-1 低于中重度组,差异有统计学意义(P<0.05);血清PTX3 与血糖水平、炎症指标、胰岛素敏感性指标正相关(P<0.05);Omentin-1 与血糖水平、炎症指标、胰岛素敏感性指标负相关(P<0.05);123 例GDM患者的不良妊娠结局发生率为26.83%(33/123);血清PTX3 对GDM不良预后的预测灵敏度、特异度分别为 82.62%、80.41%;血清Omentin-1 对GDM不良预后的预测灵敏度、特异度分别为 80.35%、79.33%(AUC>0.85).结论 血清PTX3、Omentin-1 有望成为预测GDM患者不良妊娠结局的敏感指标.
Abstract
Objective To analyze the predictive effect of serum PTX3 and Omentin-1 on adverse pregnancy outcomes in gestational diabetes mellitus(GDM).Methods 123 patients with GDM were divided into the mild group(53 cases)and moderate to severe group(70 cases)based on the degree of insulin resistance.The correlations between serum levels of PTX3,Omentin-1,GDM blood glucose,inflammatory response,and insulin sensitivity indicators,and their predictive power for adverse pregnancy outcomes were analyzed.Results Levels of FBG,2-h PG,Hcy,Cycs,NGAL,GAL,and PTX3 were higher in the moderate to severe group than in the mild group,while Omentin-1 levels were lower,showing a statistically singificant difference(P<0.05).Serum PTX3 showed a positive correlation with blood glucose levels,inflammatory markers,and insulin sensitivity markers(P<0.05).Omentin-1 was negatively correlated(P<0.05).The incidence of adverse pregnancy outcomes among the 123 GDM patients was 26.83%(33/123).Serum PTX3 and Omentin-1 had sensitivities of 82.62%and 80.35%,and specificities of 80.41%and 79.33%,respectively(AUC>0.85).Conclusion Serum PTX3 is positively correlated with the progression of GDM,while Omentin-1 is negatively correlated.Both biomarkers are promising for predicting adverse pregnancy outcomes in GDM.
维普
万方数据